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Nocid (Famotidine) 40mg, 10 Ct - AGP Digestive Enzymes An ideal daily face washFamotidine primarily work by inhibiting the action of histamine at the H2 (histamine 2) receptors in the stomach. It is a potent H2 receptor antagonist, which means it blocks the specific sites where histamine would normally bind. By doing so, famotidine decreases the production of stomach acid. This mechanism is crucial in reducing gastric acid secretion, which helps to alleviate symptoms associated with conditions like gastroesophageal reflux